Impact of surface properties of branched polyacrylamides onto model lipid membranes of various compositions

Abstract

Branched dextran-graft-polyacrylamide copolymers with different surface properties (charged and uncharged, pure and loaded by Ag or Au nanoparticles) were created in order to drug delivery usage. By means of differential scanning calorimetry, membranotropic action of the polymers was revealed in a set of model lipid membranes, both charged and uncharged. It was observed that negatively charged membranes were more sensitive to the polymers introduction then uncharged one. The most pronounced membrantoropic effects resulted from membrane surface disturbance, which is due to significant contribution and specificity of surface interaction in the systems studied.

Key Words:

• Copolymers dextran-graft-polyacrylamide
• nanoparticles
• model lipid membranes
• differential scanning calorimetry

Acknowledgement

This publication is supported in part by the grant of the State Fund For Fundamental Research (Ukraine), project Ф76/64-2017 “New multifunctional hybrid nanocomposites for photodynamic chemotherapy of tumor cells” and by the grant of the Department of Targeted Training of Taras Shevchenko National University of Kyiv at National Academy of Sciences of Ukraine, project 28Ф “Physical mechanisms of the oxygen molecules excitation in functional nanosystems for medical application”