“Synthesis and study of novel biological active chalconyl-ester based bent-core LCs: Effect of tail/lateral group”

Abstract

A newly designed homologues series: 4-bromo-2-(3-(4-dimethyl amino) phenyl) acryloyl)-6-nitrophenyl-3-(4-n-alkoxy phenyl) acrylate has been synthesized and studied through chalconyl vinyl ester linking group at (ortho) position. Novel series consisted thirteen compounds, in which C₁ to C₅ homologue are nonliquid crystal, while C₆ to C₁₈ exhibits SmC and nematic phase at enantiotropically manner. Thus, present novel series is predominantly nematogenic and partly smectogenic mesophase. Mesophase image of present compounds are schlieren like, broken fan and threaded type textures measured by POM equipped with heating stage. All this compounds were characterized by FT-IR and ¹H NMR analysis. The mesomorphism is measured by POM, DSC and molecular packing is confirmed by XRD technique. Chalconyl ester based compounds C₄ to C₁₂ shows antibacterial as well as antifungal activity compared with corresponding standard drugs. Analytical and spectral data confirmed the molecular structures of the present V-shaped bent core homologous series.

Graphical Abstract

Keywords:

• Liquid crystals
• chalcone
• enantiotropic
• nematic
• smectic

Acknowledgement

VD and RBP acknowledge thanks to Dr. R.R.Shah, principal and management of K. K. Shah Jarodwala Maninagar Science College, Ahmedabad for providing research lab and other facility. VS thanks to Department of Chemistry, Faculty of Basic and Applied Science, Sirohi, Rajasthan for providing lab facility. Authors are also thankful to NFDD Centre for providing analytical and spectral services.