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LOW-DIMENSIONAL SOLIDS AND MOLECULAR CRYSTALS

Screening and fluorescence investigation on favipiravir cocrystal

, , & ORCID Icon
Pages 102-117 | Published online: 15 Oct 2021
 

Abstract

Favipiravir was chosen as a model for study on cocrystal screening of nucleoside analog. Seven coformer candidates were selected according to supramolecular synthon method and verified with molecular modeling and hot-stage. Only 4-amino benzoic acid was able to form cocrystal with the color transformation from white to yellow. Fluorescence study was investigated and compared during cocrystallization. Due to the fluorescent emission nature of nitrogen heterocyclic nucleoside analog, fluorescence could also be utilized as a promising tool in screening cocrystals. This study provides an efficient pathway toward nucleoside analog cocrystal and affords a fluorescent screening method for drug cocrystal research.

Additional information

Funding

We appreciate the financial support by Beijing Postdoctoral Science Foundation (Grant No.: 20000031004) and Beijing Institute of Petrochemical Technology (Grant No.: 20000090002/001). We thank Dr Baozhong Lü for his help on fluorescence study.

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