Part III: Supercritical Fluid Chromatographic Separations

Abstract

The enantioseparation of 123 clinically used racemic drugs by supercritical fluid chromatography (SFC) on commercial chiral stationary phases (CSPs) available in 2006 is reviewed. The CSPs were briefly described in Part I of this work. The mobile phase compositions, with organic modifier and additives, are listed. The data was extracted and compiled from the ChirBase database (Marseille, France). All the drugs included are listed according to the thirteen therapeutic classes of the Anatomical Therapeutic Chemical (ATC) classification. It is evident that the nature of the SF mobile phase precludes the use of several classes of CSPs such as the crown ethers, ligand‐exchange or protein‐based CSPs. The polysaccharide based CSPs were responsible for two third of the enantiomer separation listed.

Keywords:

• Supercritical fluid chromatography
• chiral drugs
• enantiomers
• therapeutic activity
• SFC chiral separations
• enantioseparations
• chiral stationary phases

ACKNOWLEDGMENT

The authors thank the French CNRS, Centre National de la Recherche Scientifique, Université de la Méditerranée unit UMR6114 for GF, Université de Lyon unit UMR5180 for AB, and Université de Marseille Saint Jérôme unit UMR 6263 for PP and CR for continuous support.