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Original Articles

Preparation and Characterization of Carboxymethyl-Functionalized Chitosan Fiber

, , , , , & show all
Pages 211-221 | Published online: 07 May 2015
 

Abstract

Carboxymethyl chitosan fiber (CMCF) was successfully prepared and characterized by FTIR. The swelling behavior, mechanical property, antibacterial activity and indirect cytotoxicity assessment of CMCF were also studied, respectively. The results showed that, CMCF had higher liquid absorption capacity and lower tensile strength and elongation at break than those of chitosan fiber. The antibacterial activity of CMCF was similar with chitosan fiber, and carboxymethylation did not enhance the antibacterial activity directly. Indirect cytotoxicity assessment of the fibers indicated that CMCF was nontoxic to the L929 cell with relatively low extraction concentration. This novel fiber would be used as a potential wound dressing for skin regeneration.

Additional information

Funding

This work was financially supported by the Major State Basic Research Development Program (973 Program) (No. 2012CB722701) and National Natural Science Foundation of China (No.51203123).

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