Study of Wound Dressing Material Coated With Natural Extracts of Leaf Solution Enhanced With Recombinant Human Epidermal Growth Factor (REGEN-D^TM 150)

ABSTRACT

In the part of work, the leave extracts of aloe vera, piper betel, and neem leaf were prepared and coated on bamboo fiber-based material for wound dressing applications. The fabrics coated with different compositions of the natural extract were enhanced with recombinant human epidermal growth factor (REGEN-D™ 150). The FTIR confirms the presence of alcoholic and phenolic group which were responsible for antibacterial activity. The SEM morphology of the developed dressing material was porous nature and more suitable for the process of curing wound. In antimicrobial tests, the zone of incubation of Escherichia coli and Staphylococcus aureus ranges from 18 to 22 mm. In vivo study using albino rats induced with diabetes reveals that the wound healing rate is increased in the range of 25–54% compared to a negative control group.

摘要

本研究以芦荟、槟榔、印楝叶为主要原料，制备芦荟、槟榔、印楝叶提取物，并将其涂在竹纤维基材料上，用于伤口敷料. 用rhEGF（REGEN-D）对不同成分的天然提取物涂层织物进行增强处理™ 150页）. FTIR证实了醇基和酚基的存在，它们对抗菌活性起作用. 所制备的敷料的SEM形貌为多孔性，更适合于伤口的固化过程. 在抗菌试验中，大肠杆菌和金黄色葡萄球菌的孵育区分别为18mm和22mm. 利用糖尿病大鼠进行的体内研究表明，与阴性对照组相比，伤口愈合率在25%到54%之间.

KEYWORDS:

• Antibacterial
• antimicrobial
• bamboo
• natural extract
• physical properties
• wound dressing

关键词:

• 抗菌
• 抗菌剂
• 竹子
• 天然提取物
• 物理性质
• 伤口敷料