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Original Articles

Development and Validation of a Wipe Test Method Using Liquid Chromatography with Tandem Mass Spectrometry for the Determination of Perfluorooctanoate (PFO) on Various Surfaces

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Pages 390-395 | Published online: 17 Apr 2009
 

Abstract

Perfluorooctanoate (PFO) is the anion of perfluorooctanoic acid. As the ammonium salt, PFO has been used for 50 years as a processing aid in the commercial production of perfluorinated and highly fluorinated polymers. To assess the effectiveness of industrial hygiene controls in processes involving PFO products and intermediates, a wipe test was developed and validated to determine quantitatively the PFO concentration on six surfaces: stainless steel, polycarbonate, Formica, butyl acid suit material, laminated disposable suit material, and a painted surface. Acceptable recovery and precision results were obtained for nonporous surfaces, such as stainless steel, polycarbonate, Formica, acid suit material, and painted surfaces on a 10-cm × 10-cm surface. The analytical method was evaluated over a range of 1 to 23 ng/cm2, or 100 to 2300 ng/100 cm2. The reporting limit for the method was 100 ng/wipe.

ACKNOWLEDGMENT

The authors thank John J. Kozlowski for his help with the initial LC/MS experiments. We also thank DuPont's Industrial Hygiene working group for their valuable input.

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