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CASE REPORT

Tetrasomy 18p in a Twin Pregnancy with Diverse Expression in Both Fetuses

, , , , , , & show all
Pages 339-343 | Received 08 Feb 2016, Accepted 08 May 2016, Published online: 16 Jun 2016
 

ABSTRACT

Tetrasomy 18p, characterized by the presence of four copies of the short arm of chromosome 18, is considered to occur with the nondisjunction in meiosis II after the errors in the meiotic and early postmeiotic mitotic division in the centromere. It is accompanied by various abnormalities including congenital heart defects, lower extremity abnormalities, micrognathia, high arched palate, kyphoscoliosis, microcephaly, myelomeningocele, hernia and renal anomalies. We present the first case of a dichorionic diamniotic twin pregnancy in which both fetuses were affected by tetrasomy 18p, but with discordant morphology, detected in one twin in the first but in the other in the second trimester.

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the article.

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