Cumulative Evidence for Association between IL-10 Polymorphisms and Kawasaki Disease Susceptibility: A Systematic Review and Meta-Analysis

Abstract

Background

This meta-analysis was carried out to evaluate the associations between IL-10 polymorphisms and Kawasaki disease (KD) risk.

Methods

A comprehensive literature search was performed using PubMed, EMBASE, China National Knowledge Infrastructure and SciELO for all relevant studies evaluating IL-10 polymorphism and susceptibility to KD. The associations were measured by odds ratios (ORs) and its corresponding 95% confidence intervals (CIs).

Results

A total of 13 studies including four studies on -1082 A > G, four studies on -819 T > C and five studies on -592 A > C polymorphism were selected. Pooled data revealed that IL-10 -592 A > C polymorphism was significantly associated with an increased risk of KD (C vs. A: OR = 0.402, 95% CI 0.194–0.832, p = 0.014). However, IL-10 -1082 A > G and -819 T > C polymorphisms were not significantly associated with risk of KD under all five genetic models.

Conclusions

Our results revealed that IL-10 -592 A > C polymorphism was associated with risk of KD, while IL-10 -1082 A > G and -819 T > C polymorphisms were not involved in the development of KD.

KEYWORDS:

• Kawasaki disease
• interleukin 10
• polymorphism
• association
• meta-analysis

Acknowledgments

We specially thank Ms. Sahel Khajehnoori and Mrs. Elham Akbarian (who is currently working in the Mother & Newborn Health Research Center and Children Growth Disorder Research Center at Shahid Sadoughi University of Medical Sciences, respectively) for her help in revising the grammar issue of this manuscript.

Disclosure statement

The authors declare no conflict of interest.