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Fetal and Pediatric Pathology Volume 40, 2021 - Issue 6
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Review

Association of IL-6 -174G > C Polymorphism with Susceptibility to Childhood Sepsis: A Systematic Review and Meta-Analysis

Farzad Ferdosiana Department of Pediatrics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran;b Children Growth Disorder Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
,
Mohammad Hossein Jarahzadehc Department of Anesthesiology and Critical Care, Shahid Sadoughi University of Medical Sciences, Yazd, IranCorrespondence[email protected]
,
Reza Bahramid Neonatal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
,
Zahra Nafeia Department of Pediatrics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran;b Children Growth Disorder Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
,
Mohammadali Jafarie Department of Emergency Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
,
Ali Raee-Ezzabadie Department of Emergency Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
,
Seyed Reza Mirjalilia Department of Pediatrics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran;f Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
&
Hossein Neamatzadehf Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran;g Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
 show all
Pages 638-652 | Received 01 Jan 2020, Accepted 13 Jan 2020, Published online: 14 Feb 2020
 
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Abstract

Background

This meta-analysis evaluates the correlation between the IL-6 -174 G > C polymorphism and susceptibility of childhood sepsis. Methods: We searched PubMed, ISI Web of Knowledge, Scopus, CNKI, SID, SciELO databases until December 30, 2019 to identify all eligible studies. Results: A total of 17 studies with 1,287 cases and 2,482 controls were identified. Pooled data revealed that there was no significant association between the IL-6 -174 G > C polymorphism and risk childhood sepsis in the overall population. When stratified analysis was carried out by age group of cases, no associations were found in neonates and pediatrics. However, in ethnicity-based subgroups, a significant association was found in Caucasians and Africans. Conclusions: There was no significant association of the IL-6 -174G > C polymorphism with susceptibility to sepsis in childhood overall, but there was an association with the Caucasian and African ethnic subgroups.

Acknowledgements

The authors thank the editors and the anonymous reviewers for insightful suggestions on this study.

Disclosure statement

No potential conflict of interest was reported by the authors.

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