Maternal Adverse Outcomes in Hypertensive Disorders of Pregnancy and Their Association with Serum Adiponectin and Redox Markers

Abstract

Background: Premature termination of pregnancy because of unmanageable maternal complications in hypertensive disorders of pregnancy (HDP) results in adverse neonatal outcome. Identification of biochemical derangements associated with maternal complications may help in the better medical management of the mother resulting in better neonatal outcomes. Method: Healthy pregnant women (C); pregnant women with gestational hypertension (GH), and preeclampsia (late [LP] and early [EP] onset) were studied. Maternal serum redox markers and adipokines were evaluated for their association with maternal complications. Results: Adiponectin levels were significantly raised in preeclampsia groups when compared with control and GH groups. Univariate and multivariate analysis confirmed that malondialdehyde (MDA) and total antioxidant status (TAS) were associated with eclampsia; adiponectin and TAS with HELLP syndrome; adiponectin, MDA and TAS with severe preeclampsia; and adiponectin with impaired renal function. Conclusion: We identified that increased serum adiponectin, MDA, and TAS were associated with adverse maternal outcomes.

Keywords:

• adipokines
• early onset preeclampsia
• gestational hypertension
• late onset preeclampsia
• maternal outcome
• redox markers

Acknowledgments

We thank Dr Deepak Paulose and Dr Smitha Mariam Koshy for their support during manuscript preparation.

Conflict of interest

None

Additional information

Funding

This work was funded by extramural research grants from Department of Biotechnology, Ministry of Science and Technology, Government of India and Indian Council of Medical Research (ICMR), Department of Health Research, Ministry of Health and Family Welfare, Government of India. It was also funded by intramural research grant from JIPMER, Ministry of Health and Family Welfare, Government of India.