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Case Reports

Infantile Inflammatory Myofibroblastic Tumor of Spleen

ORCID Icon, , , & ORCID Icon
Pages 475-479 | Received 03 Sep 2020, Accepted 29 Sep 2020, Published online: 23 Oct 2020
 

Abstract

Background: Inflammatory myofibroblastic tumor (IMT) is a mesenchymal neoplasm with unknown etiology and recurrent potential. They are widely reported in children and young adults. Nearly 50% of inflammatory myofibroblastic tumor harbor rearrangement in anaplastic lymphoma kinase (ALK) gene with the majority expressing ALK protein. ALK-negative IMTs harbor alteration in ROS1 gene in a subset of cases. Few reports have shown association of IMT with Epstein–Barr virus (EBV). Case report: We report a case of IMT of the spleen in an 18-month-old infant presenting with abdominal distention and failure to thrive. Workup for ALK-1, ROS1, and EBV small-encoded RNA in-situ hybridization using immunohistochemistry was negative. Conclusions: IMT can arise in an infant spleen.

Disclosure statement

The authors report no conflicts of interest.

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