https://orcid.org/0000-0002-4062-0904
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Abstract
Introduction: Pediatric DLBCL is considered a homogenous group and has superior outcomes compared to adults. This study investigated the clinical pathology and immunohistochemical distinction between adult and pediatric large B-cell lymphoma. Methods: A cross-sectional study of 314 NHLs with the morphology of diffuse pattern, large B-cell, and CD20 expression was investigated. Results: Of 314 cases, there were 6 cases of pleomorphic MCL (all in adults), 19 cases of Burkitt lymphoma (all in children), and 289 cases of DLBCL. Pediatric DLBCL had many striking differences: More frequency in extra-nodal sites; a higher proportion of centroblastic morphology; a predominance of GCB-type; a high proliferation rate; an infrequency of Bcl2 protein expression, and a lack of double-expresser lymphoma. Conclusions: Our study demonstrated the significant biological differences between adult and pediatric DLBCL.
Author contributions
Conceptualization: TDAP, ULL, TDT. Data curation: TDAP, TDT, TTL, MHD, ULL, DTNP. Formal analysis: TDAP, ULL, DTNP. Funding acquisition: TDAP, DQN, HTTN. Methodology: TDAP, DQN, ULL. Resources: NDTT, TAT, ULL, TDAP. Supervision: DQN, NDTT, TAT, HTNH, TTPD. Writing—original draft: TDAP, DTNP, ULL. Writing—review and editing: TDAP, DTNP, QDN. Approval of final manuscript: all authors.
Disclosure statement
No potential competing interest was reported by the authors.
Ethics statement
The study was approved by the Institutional Review Board of Ethics in Biomedical Research, University of Medicine and Pharmacy at Ho Chi Minh City (IRB No. 204/UMP-BOARD; date: March 9, 2020) and performed by the principles of the Declaration of Helsinki. Written informed consents were obtained.