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Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry Volume 36, 2006 - Issue 10
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Original Articles

Synthesis, Characterization, and Cytotoxic Properties of Platinum(II)‐Amine Complexes. X‐ray Crystal Structure Determination of [Pt(C6H12N4)Cl2] · 3H2O

Kui Cheng Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, People's Republic of China; Department of Chemistry, Wuhan University of Science and Engineering, Wuhan, People's Republic of China
,
Hai‐Liang Zhu Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, People's Republic of China; Department of Chemistry, Wuhan University of Science and Engineering, Wuhan, People's Republic of ChinaCorrespondence[email protected]
&
Zhi‐Bin Li Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, People's Republic of China; Department of Chemistry, Wuhan University of Science and Engineering, Wuhan, People's Republic of China
Pages 719-722 | Received 16 Jul 2006, Accepted 29 Aug 2006, Published online: 15 Feb 2007
 
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Three platinum(II) complexes of amines(L) have been prepared and structurally characterized and activity determined, where L is triethylenediamine, hexamethylenetetramine or pyridine, respectively. Crystal structure of [Pt(C6H12N4)Cl2] · 3H2O was determined by X‐ray single analysis, indicating that it is a cis‐compound, and with the space group of C2/c, monoclinic, and a=27.540(2) Å, b=9.175(5) Å, c=9.996(3) Å, β=104.37(3)°, U=2447.1(2) Å3, Z=8, Dx=2.466 g cm−3. The result of antitumor activity assay indicated that these complexes inhibited the growth of several human solid carcinoma cell lines strongly.

The work was financed by grant (project 30572516) from National Natural Science Foundation of China.

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