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Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry Volume 37, 2007 - Issue 7
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Original Articles

Chemical Aspects of Organotin Derivatives of Beta‐diketones, Quinonoids, Steroids and Some Currently Used Drugs: A Review of the Literature with Emphasis on the Medicinal Potential of Organotins

Vasiliki Valla Department of Chemical Engineering, Aristotle University of Thessaloniki, Thessaloniki, GreeceCorrespondence[email protected]
&
Maria Bakola‐Christianopoulou Department of Chemical Engineering, Aristotle University of Thessaloniki, Thessaloniki, Greece
Pages 507-525 | Received 28 Jan 2007, Accepted 07 Mar 2007, Published online: 14 Sep 2007
 
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The last 50–70 years there has been an increasing interest on organotin compounds mainly because of their industrial, agricultural and biological applications. This review aims to offer a substantial overview of the organotin complexes of beta‐diketones and beta‐diketone derivatives, quinonoids, steroids and NSAIDs describing their structure, coordination mode and properties. Discussion will be focused on the interaction of organotins with endocrine systems and especially on their ability to interfere with sex steroid hormones and relative enzymes as well as with their current status as potential therapeutics for malignancies, inflammations, and infections.

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