A Weak Hydrolytical Copper(II) Complex Derived from Condensation of N,N‐Dimethylbiguanide with 2‐Pyridinecarbaldehyde Synthesis, Crystal Structure and Biological Activity

The project was supported by Open‐end Funds of Jiangsu Key Laboratory of Marine Biotechnology, Huaihai Institute of Technology (No. 2006HS007).

[CuLCl], a copper(II) complex derived from weak nucleophilic addition of complex [CuL′Cl], which was synthesized by Schiff base condensation of N,N‐dimethylbiguanide with 2‐pyridinecarbaldehyde in the presence of Cu(ClO₄)₂ · 6H₂O, has been synthesized and characterized by single‐crystal X‐ray diffraction. Cu(1) locates in a N₃Cl coordination environment and possesses a slightly distorted square planar configuration. Antimicrobial activity study found that the complex was active against Staphylococcus aureus CMCC (B) 26 003, Bacillus pumilus CMCC (B) 63 202, Salmonella CMCC (B) 50 094 and Eschierichia Coli CMCC (B) 44 102, but the activity was somewhat weaker than [CuL′Cl].

Keywords:

• copper(ІІ) complex
• N,N‐dimethylbiguanide
• Schiff base
• hydrolysis
• crystal structure
• antimicrobial activity

Acknowledgments

Financial support from Lianyungang Technical College (YKJ200712) and Jiangsu Key Laboratory of Marine Biotechnology, Huaihai Institute of Technology (2006HS007) is gratefully acknowledged.

Notes

The project was supported by Open‐end Funds of Jiangsu Key Laboratory of Marine Biotechnology, Huaihai Institute of Technology (No. 2006HS007).