Synthesis and Characterization of 3, 4, 5-triphenolbenzoylsalicylaldehyde Hydrazone and its Rare Earth Metal Complexes with Antitumor Activities

Abstract

A new gallic acid derivative, 3, 4, 5-triphenolbenzoylsalicylaldehyde hydrazone (HL), and its four rare earth metal complexes, [LnL (OAc)₂] · H₂O (Ln = La^{3 +}, Sm^{3 +}, Tb^{3 +}, Dy^{3 +}), have been synthesized and characterized on the basis of elemental analyses, molar conductivity, IR and ¹H NMR spectra. The antitumor activities against HL-60 and A − 549 cell lines of the prepared compounds have also been evaluated. The results indicate that the antitumor activity against the human leukemia cell lineHL-60 than the ligand HL, and the antitumor activity of the ligand is largely changed by the formation of the complexes.

Keywords:

• antitumor activity
• complexes
• hydrazone
• rare earth metals
• synthesis

The work is supported by Leading Academic Discipline Project of Shanghai Municipal Education Commission (Project No. 530109) and the Research Award Fund for Outstanding Young Teachers in Shanghai Higher Education Institutions (Grant No. 17021).

Notes

^a Molar conductance, concentration of the solution in DMSO was about 10^{− 3} mol/dm³.

^b 72h, SRB method

^a 72h, MTT method.