Syntheses and Crystal Structures of Two Schiff Base Copper(II) Complexes with Urease Inhibitory Activity

Abstract

Two new copper(II) complexes, [CuBrL1] (1) and [CuBrL2] (2) (HL1 = 1-[(2-diethylaminoethylimino)methyl] naphthalen-2ol, HL2 = 2,4-dibromo-6-[(2-diethylaminoethy limino) methyl]phenol), were prepared and structurally characterized by elemental analyses, infrared spectroscopy, and single-crystal X-ray diffraction. Both complexes are mononuclear copper(II) compounds. The Cu atom in each of the complexes is four-coordinate in a square planar geometry. Both complexes show potent urease inhibitory activities.

Keywords:

• Schiff base
• copper(II)
• synthesis
• crystal structure
• urease inhibitory activity

This project was financially supported by the Natural Science Foundation of China (No. Y407318) and the Science and Technology Plan of Huzhou (No. 2007YS18).

Notes

^a R ₁ = ∑ ‖Fo| − |Fc‖/∑ |Fo|, wR ₂ = [∑ w(Fo ²− Fc ²)²/∑ w(Fo ²)²]^1/2.