Synthesis, Characterization, and Antimicrobial Activities of Macrocyclic Complexes of Divalent Transition Metal Ions

Abstract

A novel series of complexes of the type [M(C ₃₆ H ₂₂ N ₆ )X ₂ ]; where M = Co(II), Ni(II), Cu(II) and Zn(II); X = Cl⁻, NO₃ ⁻, CH₃COO⁻has been synthesized by template condensation of 1,8-diaminonaphthalene and Isatin in the presence of divalent metal salts in methanolic medium. The complexes have been characterized by elemental analyses, conductance and magnetic measurements, UV/Vis, NMR, IR and MS spectroscopy. On the basis of these spectral data, a distorted octahedral geometry may be proposed for all of these complexes. All synthesized macrocyclic complexes were tested for in vitro antimicrobial activities against some pathogenic bacterial and fungal strains.

Keywords:

• antimicrobial activity
• Isatin
• macrocyclic complexes
• spectroscopic studies

D. P. Singh thanks the University Grants Commission, New Delhi for financial support in the form of Major Research Project [MRP-F.No.32-196/2006(SR)] and Krishan Kumar for the award of Project Fellowship under the above project. Thanks are also due to authorities of N.I.T., Kurukshetra for providing necessary research facilities.

Notes

^x Values, including diameter of the well (8 mm), are means of three replicates