Abstract
A simple, high-yielding synthesis of 2,4,5-trisubstituted imidazoles from 1,2-diketone/1,2-hydroxyketone and aldehydes in the presence of NH4OAc is described. Under solvent-free conditions, aryl and heteroaryl substituted imidazoles are formed in yields ranging from 70 to 90%.
Acknowledgments
MMH is thankful to the Iran National Science Foundation for partial financial support.