Synthesis of Ferrocenyl Pyrrolizidines Through [3+2] Cycloaddition of Azomethine Ylides

Abstract

Numerous derivatives of ferroenyl pyrrolizidines containing cyano groups were successfully synthesized in moderate yields via a facile [3+2]-cycloaddition reaction of several azomethine ylides (derived from several aromatic aldehydes and proline) with 1,1-dicyano-2-ferrocenylethene as the dipolarophile in refluxing toluene. Assignment of the molecular structure was carried out by single-crystal X-ray diffraction.

Keywords:

• azomethine ylides
• cycloaddition
• ferrocene
• pyrroli- zidines

Acknowledgments

This work was financially supported by Hebei Province science and technology support plan project (11207184D) and the fund of Hebei University of Science & Technology (No. XL201137).