Rhodium(III) Catalyzed and Uncatalyzed Kinetic Spectrophotometric Oxidation of Amodiaquine Hydrochloride With Chloramine-T in Presence of Alkaline Buffer: A Mechanistic Chemistry

Abstract

Amodiaquine hydrochloride (AQ) is a 4-aminoquinoline derivative commonly used to prevent and treat malaria. Sodium N-chloro-p-toluenesulfonamide or chloramine-T (CAT) is a well-known oxidizing agent. In rhodium(III) chloride (Rh(III)) catalyzed oxidation, the rate law is -d[CAT] / dt = k [CAT]_o [AQ]_o [OH^–]^–x [Rh(III)]^y and it takes the form -d[CAT]/dt = k [CAT]_o[AQ]_o[OH^–]^–x for uncatalyzed reaction, where x and y are less than unity. The rate constants revealed that the Rh(III) catalyzed reactions are about five fold faster than the uncatalyzed reactions. The catalytic constant (K_C) and activation parameters with respect to Rh(III) catalyst have been deduced.

Keywords:

• AQ-CAT
• oxidation kinetics
• Rh(III) catalyst

Acknowledgments

Dr. Sukhdev thanks the Principal and the Management of MES College of Arts, Commerce and Science for encouragement.