Microwave-Assisted Synthesis, Crystal Structures, and In Vitro Antibacterial Studies of Cobalt(III) and Vanadium(V) Complexes Derived From N,N’-1,2-propylene-bis(3-methylsalicylideneimine)

Abstract

The syntheses of a mononuclear cobalt(III) complex [CoL(NCS) (OH₂)] and a mononuclear vanadium(V) complex [VOL(NCS)] (H₂L = N,N′-1,2-propylene-bis(3-methylsalicylideneimine)), by a one-step sequence from the reaction of H₂L, ammonium thiocyanate and metal salts under microwave irradiation are described. The newly prepared complexes were characterized by a combination of elemental analyses and IR spectra. Their structures were determined by single-crystal X-ray crystallography. Both complexes with octahedral metal centers have similar structures. The crystal of the cobalt complex is stabilized by hydrogen bonds, while there are no such interactions in the crystal of the vanadium complex. In order to evaluate the biological activity of H₂L and to evaluate the role of cobalt and vanadium ions on biological activity, the free ligand and the complexes have been studied in vitro antibacterial against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Pseudomonas aeruginosa.

Keywords:

• antibacterial activity
• cobalt complex
• crystal structure
• microwave-assisted synthesis
• vanadium complex

Acknowledgments

Financial assistance from the Qiqihar University is gratefully acknowledged.