Preparation, X-Ray Structures, and Cytotoxic Property of Mononuclear Schiff Base Zinc Complexes [Zn(SalPr)₂] and [ZnI₂(SalPt)₂]

Abstract

Schiff bases obtained from 5-chlorosalicylaldehyde with cyclopropylamine, and 4-methoxysalicylaldehyde with cyclopentylamine, were used as ligands for Zn(II) resulting in two mononuclear zinc complexes, [Zn(SalPr)₂] and [ZnI₂(SalPt)₂], where SalPr is 4-chloro-2-(cyclopropyliminomethyl)phenolate and SalPt is 2-(cyclopentyliminiummethyl)-5-methoxyphenolate. The detailed structures of the complexes were determined by single crystal X-ray crystallography. Coordination sphere of Zn(II) atoms in both complexes are slightly distorted tetrahedron. The cytotoxic property of the complexes was evaluated.

Keywords:

• aromatic Schiff base ligand
• cytotoxic property
• mononuclear zinc complex
• salicylaldimine derivatives
• X-ray structures

Acknowledgments

This work was supported by the Science and Technology Support Projects of Gansu Province (Grant No. 1204NKCA107), the Engineering and Technology Center Projects of Gansu (Grant No. 1106NTGA013), and ‘Qing Lan’ Talent Engineering Funds of Lanzhou Jiaotong University.