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Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry Volume 44, 2014 - Issue 7
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Original Articles

Synthesis, Structure, and DNA Interaction of a New Ternary Copper(II) Complex With 2-(4′-thiazolyl)benzimidazole and L-isoleucinate

Zhi-Bin Ou Department of Applied Chemistry, South China Agricultural University, Guangzhou, P. R. China
,
Jia-Min Su Department of Applied Chemistry, South China Agricultural University, Guangzhou, P. R. China
,
Xia-Bing Fu Department of Applied Chemistry, South China Agricultural University, Guangzhou, P. R. China
,
Yan-Mei Lu Department of Applied Chemistry, South China Agricultural University, Guangzhou, P. R. China
&
Xue-Yi Le Department of Applied Chemistry, South China Agricultural University, Guangzhou, P. R. China; Institue of Biomaterial, South China Agricultural University, Guangzhou, P. R. China
Pages 959-966 | Received 09 Apr 2012, Accepted 10 Apr 2013, Published online: 04 Mar 2014
 
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Abstract

A new ternary copper(II) complex: [Cu (TBZ)(L-Ile)] ClO4·2H2O [TBZ = 2-(4′-thiazolyl) benzimidazole, L-Ile = L-isoleucinate], was synthesized and characterized by elemental analysis, molar conductivity, IR, UV-vis spectroscopy, and single-crystal X-ray diffraction method. The interaction of the complex with DNA was investigated by electronic absorption spectroscopy, fluorescence spectroscopy, CD spectroscopy, viscosity measurements, and agarose gel electrophoresis. The results indicated that the complex could bind to DNA by intercalative mode, and cleave pBR322 DNA in the presence of vitamin C in the involvement of hydroxyl radicals, and probably singlet oxygen-like copper-oxo species.

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