Synthesis and Structures of Copper(II) and Nickel(II) Complexes Derived from 2-Methyl-6-[(2-Morpholin-4-ylethylimino)Methyl]Phenol with Antimicrobial Activity

Abstract

A new Schiff base compound, 2-methyl-6-[(2-morpholin-4-ylethylimino)methyl]phenol (HL), derived from 3-methylsalicylaldehyde and 2-morpholin-4-ylethylamine, and its copper(II) and nickel(II) complexes [CuL(N₃)] (1) and [NiL(NCS)] (2), have been prepared and characterized by elemental analyses, IR, and single crystal X-ray crystallographic determination. The crystal of (1) is triclinic: space group P, a = 8.9887(7), b = 9.4007(7), c = 10.2218(8) Å, α = 79.9600(10), β = 64.1580(10), γ = 87.7490(10)^o, V = 764.81(10) ų, Z = 2. The crystal of (2) is monoclinic: space group P2₁/n, a = 10.1249(5), b = 13.2789(7), c = 12.2445(7) Å, β = 103.6490(10)^o, V = 1602.60(15) ų, Z = 4. The Schiff base ligand coordinates to the metal atoms through phenolate O and imine N atoms. The effect of the complexes on the antimicrobial activity against Staphylococcus aureus, Escherichia coli, and Candida albicans was studied.

Keywords:

• Antimicrobial activity
• copper complex
• crystal structure
• nickel complex
• Schiff base