Synthesis Soluble Non-Ion Transition Metal Manganese(II), Cobalt(II), Nickel(II) Complexes of Diethylenetriamine-N,N′,N″-tri(acetyl-p-hydroxybenzoyl hydrazine)- N,N″- Bisacetic Acid as Potential Contrast Enhancement Agent

Abstract

A novel ligand, diethylenetriamine-N,N′,N″-tri(acetyl-p-hydroxybenzoyl hydrazine)-N,N″-bisacetic acid, and its three soluble non-ion transition metal complexes, ML· nH₂O (M = Mn, n = 4; M = Co, Ni, n = 2) have been synthesized and characterized on the basis of elemental analysis, molar conductivities, ¹H NMR, FAB-MS, TG-DTA analysis, and IR methods. In addition, relaxivity of complexes are determined, The relaxivity (R₁) of MnL, CoL, NiL, and Gd(DTPA)^2– used as control are 6.33, 2.71, 2.60, and 4.34L·mmol⁻¹·s⁻¹, respectively. The spin-lattice relaxivity of MnL are larger than that of Gd(DTPA)²⁻. The results showed that complex of MnL may be a potential MRI contrast agent with high spin-lattice relaxivity, good solubility, low osmotic pressure due to non-ion complex.

Keywords:

• diethylenetriamine-N
• N′
• N″-tri(acetyl-p-hydroxybenzoyl hydrazine)-N
• N″-bisacetic acid
• transition metal complexes
• relaxation properties
• MRI contrast agent

Additional information

Funding

The project was supported by the National Natural Science Foundation (81060118, 81071144), Jiangxi Provincial Department of Education's Item of Science and Technology (GJJ09341), and Jinggangshan University Natural Science Item (JZ0813).