Synthesis of (S)-(-)-Propranolol by Using Cs_2.5H_0.5PW₁₂O₄₀ Nanocatalyst as Green, Eco-Friendly, Reusable, and Recyclable Catalyst

Abstract

The Cs_2.5H_0.5PW₁₂O₄₀ nanoparticle catalyst appear to be a new and efficient solid acid catalyst for an economical, environmentally benign synthesis of (S)-(-)-propranolol. Cs_2.5H_0.5PW₁₂O₄₀ nanocatalyst are used as a new, recyclable and reusable. Synthesis of (S)-(-)-propranolol is carried out in two steps with usual reagents: heteropolyacid, (+)-tartaric acid catalyzed enantioselective synthesis of (S)-(-)-propranolol via kinetic resolution of key intermediate α-naphthyl glycidyl ether with high optical and chemical yield. With this synthesis, we have two products in the first reaction and it is not necessary to purify the crude oil. This by-product is removed in the second step by extraction and yield is satisfactory. The nanocatalyst of Cs_2.5H_0.5PW₁₂O₄₀ catalyzed the synthesis of propranolol in high yields and good selectivity.

Keywords:

• cesium heteropolytungstate
• nanoparticles
• (S)-(-)-propranolol
• catalyst
• heteropolyacid
• recyclable
• reusable