Metal-Based Antibacterial Agents: Synthesis, Characterization, and Biological Evaluation of Ternary Mn(II) and Co(II) Complexes Containing Sulfamethoxazole and Cephalosporins

Abstract

Manganese(II) and cobalt(II) react with cephalosporins antibiotics (cefazolin, ceftriaxone, and cefepime) plus sulfamethoxazole (Hsmz) to form the following mixed ligand complexes of general formulas [M(L)(smz)(H₂O)₂] (L^1,2, L = monoanion of cefazolin HL¹, ceftriaxone HL²; M = Mn(II), Co(II)) and [M(L³)(smz)(H₂O)Cl] (cefepime L³), which were characterized by physicochemical and spectroscopic methods. The nature of bonding and the stereochemistry of the complexes have been deduced from elemental and thermal analyses, infrared, electronic spectra, magnetic susceptibility, EPR, and conductivity measurements. An octahedral geometry has been suggested for the complexes. Their spectra indicated that cephalosporins and Hsmz are acting as monoanionic bidentate chelating agents. They have been screened for their antibacterial activity and the results are compared with the activity of commercial cephalosporins.

Keywords:

• mixed ligand complexes of Mn(II) and Co(II)
• cephalosporins complexes
• antibacterial metal complexes

Acknowledgments

The authors are grateful to Lic. Alfreisa Rodriguez for the antibacterial activity tests.

Additional information

Funding

The authors are grateful to the Comisión de Investigación at the Universidad de Oriente for providing financial support.