Abstract
Reduced Schiff base ligand by condensation of phenylalanine analogue containing 2,3-diaminopropionic acid (DAP) with salicylaldehyde and its oxovanadium(IV) complex have been prepared. Chemical and structural properties were fully characterized. Density functional theory was used to pin down the structure combined with IR. The natural bond orbital analysis and energy calculations indicate that tetracoordinated complex of R-type is the most probable structure where vanadium atom is coordinated to 2 × Ophenolate and 2 × Nimine of the ligand. By biological evaluation, the metal complex exhibits antibacterial activity against four bacterial strains and antitumor activity against two tumor cell lines.
Supplementary Material
Experimental and theoretical predicted IR spectra, ORTEP presentations and crystal data for CCDC-936085 (4) and CCDC-936084 (6) are supported. Crystallographic data can be also acquired free of charge via http://www.ccdc.cam.ac.uk/conts/retrieving.html, or from the Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge CB2 1EZ, UK; E-mail: [email protected].