Three-Dimensional Supramolecular of 2-(γ-Aminopropyl)benzimidazole Dichloride Dihydrate via Various Hydrogen Bonds and X···π (X = π, CH) Interactions: Synthesis, Crystal Structure, Characterization, and Biochemical Property

Abstract

The title compound, 2-(γ-aminopropyl)benzimidazole dichloride dihydrate ([H₂APB²⁺][Cl⁻]₂·2H₂O), was synthesized and characterized by elemental analysis, IR, UV, ¹H NMR, and fluorescent spectroscopic method. Single-crystal X-ray analysis was performed, which reveals that the benzimidazole and amine nitrogen atoms are protonated. The [H₂APB²⁺] ions are linked into a 3D framework by chloride ions and two water molecules via hydrogen bonds, C‒H···π and π-π packing interactions between adjacent benzimidazole rings. Antibacterial activities of [H₂APB²⁺][Cl⁻]₂·2H₂O have been studied on the strains S. aureus and E. coli.

Keywords:

• 2-(γ-Aminopropyl)benzimidazole
• crystal structure
• hydrogen bonds
• π-π interactions
• biochemical property