A Series of Taurocholic Acid Complexes, Spectral, Kinetic, Molecular Modeling, and Antiviral Activity Studies

Abstract

A series of taurocholic acid complexes was prepared with Cr(III), Fe(III), Co(II), Ni(II), and Cu(II) ions. The IR and Raman spectral data reveal the coordination of acid as mononegative bidentate. NH, and sulfonate (–O⁻). The bidentate mode of coordination is proposed toward all the metal ions. The electronic spectral data as well as the magnetic moment measurements proposed the octahedral geometry for all investigated complexes. The presence of water molecules was supported by thermal analysis study. ESR spectrum of Cu(II) complex was carried out and acting as a further supporting for the octahedral geometry. The molecular modeling was performed for all complexes to assert on the lower energy content for all isolated complexes in comparing with their free ligand. Such concludes the comparative stability of all isolated complexes. Scanning electron micrography for the Cu(II) complex reveals the particle size is presented in the nano range. An elaborated biological investigation was carried out for all complexes in comparison with their free ligand. The highest antiviral activity was observed with the free ligand and its Ni(II) and Co(II) complexes and moderate activity was observed with Cr(III) and Fe(III) complexes, but the lowest activity was observed with Cu(II) complex.

Keywords:

• taurocholic acid complexes
• Raman
• EPR
• thermal
• antiviral activity