Kinetics and Mechanism of Cerium(IV) Oxidation of Fosfomycin Disodium Salt: An Antibiotic Drug in Acid Perchlorate Solutions

Abstract

The kinetics of the oxidation of fosfomycin disodium salt by cerium(IV) in an aqueous perchloric acid medium at constant ionic strength, I = 1.10 mol dm⁻³, has been investigated spectrophotometrically at 25°C. The reaction is of first order in cerium(IV) concentration, fractional order in both fosfomycin and H⁺ ion concentrations. The active species of oxidant is found to be Ce(OH)³⁺. Based on the experimental results a suitable mechanism is proposed. The reaction constants involved in the different steps of the reaction mechanism and the activation parameters with respect to the slow step of the mechanism are determined and discussed.

Keywords:

• kinetics
• mechanism
• oxidation
• fosfomycin
• cerium(IV)

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