Metal-Ion Directed Synthesis of 18-Membered Tetrathia Macrocyclic Complexes of Co(II), Ni(II), Cu(II), and Zn(II), Their Physicochemical Studies and DNA Binding Study of Copper Complex

Abstract

18-membered tetrathia macrocyclic complexes of the type [MLX₂], [M = Co(II), Ni(II), Cu(II), and Zn(II), X = Cl or NO₃] have been synthesized by template condensation of α,α′-dibromo-o-xylene and 1,3-propanedithiol. The complexes have been characterized by elemental, ESI-mass, spectral (IR and NMR), molar conductance and magnetic susceptibility analysis. XRD has been used to deduce the morphology of the complex. The Absorption and fluorescence studies of Cu(II) complex show a significant binding to calf-thymus DNA. Among all composition, Cu(II) complex has showed crystalline behavior and significant binding with calf thymus DNA.

Keywords:

• tetrathia macrocyclic complexes
• template synthesis
• spectral studies
• octahedral complexes
• XRD
• DNA binding studies

Acknowledgments

The Chairman, Department of Chemistry, Aligarh Muslim University, India, is acknowledged for providing necessary research facilities. The authors thank the Regional Sophisticated Instrumentation Center CDRI (Lucknow) for ¹H and ¹³C NMR, ESI-mass and analytical data and Department of Applied Physics, AMU Aligarh, India for XRD analysis of the complexes.