Palladium(II) and Antimony(III) Complexes Derived From 2-Benzoylpyridine N⁴-Phenylthiosemicarbazone: Synthesis, Crystal Structure, Antiproliferative Activity, and Low Toxicity on Normal Hepatocyte QSG7701 Cells

Abstract

Two metal complexes [Pd(L)Cl] (1) and [Sb(L)Cl₂] (2), where HL = 2-benzoylpyridine N⁴-phenylthiosemicarbazone, have been synthesized. Complex 1 was characterized by elemental analysis, IR, UV-Vis, NMR spectroscopy, and single-crystal X-ray diffraction studies. Complex 1 contains mononuclear neutral molecules composed of one N₂S tridentate anionic thiosemicarbazone ligand and one ancillary chloride ion with a four-coordinated palladium ion. Both the two complexes exhibited enhanced cytotoxicity compared to the thiosemicarbazone and complex 2 could distinguish hepatocellular carcinoma HepG2 cells from normal hepatocyte QSG7701 cells.

Keywords:

• thiosemicarbazone
• palladium(II)
• antimony(III)
• crystal structure
• cytotoxicity

Funding

This work was financially supported by the National Natural Science Foundation of China (21071043), the Natural Science Foundation of Henan Province (132300410146) and Students' Innovation Training Program of Henan University (13NB052).

Supplementary Material

Crystallographic data for the structural analyses reported in this article have been deposited with the Cambridge Crystallographic Data Centre with CCDC 946917. Copies of this information may be obtained free of charge from The Director, CCDC, 12 Union Road, Cambridge, CB2 1EZ, UK (Fax: t44 1223 336033; E-mail: [email protected]).