Sulfamic Acid Supported Magnetic Fe₃O₄ Nanoparticles Catalyzed Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones/Thiones

Abstract

Sulfamic acid supported on magnetic Fe₃O₄ nanoparticles catalyzed the condensation reaction of aldehydes, 1,3-dicarbonyl compounds, and urea or thiourea in the synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones under solvent-free conditions. This method offers several advantages including high yield, short reaction time, ease of separation, and recyclability of the magnetic catalyst.

Keywords:

• magnetic
• Fe₃O₄ nanoparticles
• acylation
• Biginelli reaction
• dihydropyrimidin-2(1H)-one/thione