Synthesis, Crystal Structure, and Cytotoxic Property of Zinc(II) Complex Derived From N,N'-bis(5-fluorosalicylidene)-1,2-diaminoethane

Abstract

The synthesis and crystal structure of a new mononuclear zinc(II) complex derived from N,N'-bis(5-fluorosalicylidene)-1,2-diaminoethane (H₂L) are described. The infrared spectrum and thermal analysis of the complex are also discussed. X-ray diffraction indicates that the Zn atom is coordinated by two nitrogen and two oxygen atoms of the Schiff base ligand, and by one methanolic oxygen atom, to form square pyramidal coordination geometry. In the crystal, the molecules are linked through intermolecular hydrogen bonds of types O–H···O and C–H···Cl, to form 2D layers parallel to the ab plane. In vitro study shows that the complex is cytotoxic against some human fungal and bacterial pathogens.

Keywords:

• Schiff base ligand
• zinc complex
• X-ray structure
• hydrogen bonding
• cytotoxic

Supplementary Material

Crystallographic data for structural analyses have been deposited with the Cambridge Crystallographic Data Centre, CCDC No. 991137. Copies of this information may be obtained free of charge from The Director, CCDC, 12 Union Road, Cambridge, CB2 1EZ, UK (fax: [phone]; e-mail: [email protected] or http://www.ccdc.cam.ac.uk).

Funding

The author acknowledges the Linyi University for supporting this work.