Bis(pyridazine-5-olate-4-carboxylate)manganese hydrate: Synthesis, characterization, and in vitro antitumor activities

ABSTRACT

New complex of Mn(C₅H₄N₂O₃)₂(H₂O)₂·H₂O (1) where C₅H₄N₂O₃ is pyridazine-5-olate-4-carboxylate (HPZOC) has been prepared by hydrothermal reaction and structurally characterized by X-ray single-crystal diffraction analysis, FT-IR spectroscopy, elemental analysis, and thermogravimetric analyses. In complex 1, each Mn²⁺ ion is six-coordinated by six O atoms with chelating mode from the two HPZOC ligands and two water molecules. It was found that complex 1 exhibits good inhibition of the proliferation of MCF-7 and HeLa cells in vitro. Furthermore, the cell apoptosis of complex 1 against MCF-7 cells is detected by Annexin V/propidium iodide flow cytometry.

KEYWORDS:

• Pyridazine-5-olate-4-carboxylate
• manganese complex
• antitumor activity
• Annexin V/PI flow

Funding

This work was supported by grants from the Domestic Senior Visiting Scholar Funded Projects of Jiangsu Province (2014FX007), Jiangsu Overseas Research & Training Program for University Prominent Young & Middle-aged Teachers and Presidents (2015), and Industry Academic Research Prospective Joint Research Project of Jiangsu Province (BY2015032-01).