Preparation and Physico-Chemical Studies of Some Novel Mixed-Ligand Cyanonitrosyl {CrNO}⁵ Complexes of Chromium(I) with Some Antimalarial, Antibacterial and Antidyspeptic Drugs

Abstract

A new series of mixed-ligand cyanonitrosyl {CrNO}⁵ complexes of chromium(I) of compositions [Cr(NO)(CN)₂(L-L)(H₂O)] (where L-L = primaquine diphosphate, camoquin dihydrochloride, quinine monohydrochloride, cinchonine monohydrochloride, chloroquine diphosphate or chloroquinaldol) and [Cr(NO)(CN)₂(L)₂(HO)](where L = bilamide) hare been synthesized by the interaction of the potassium pentacyanonitrosylchromate(I) mnnohydrate with the said drugs L-L and L. The complexes so obtained are characterized by elemental analyses, molar conductances, magnetic measurements, thermogravi-metric analysis, electron spin resonance and infra-red spectral studies. The over all I. R. spectral studies suggest that all the liganda (except bilamide which behaves as monodentate) behave as bidentate ligands. The complexes are thermally stable up to 300°c, are paramagnetic with respect to one unpaired electron and give a positive Griess reagent test. Chromium(I) contains the low-spin {CrNO}⁵ electron configuration in all the complexes.