Efficacy of Hydroxocobalamin for the Treatment of Acute Cyanide Poisoning in Adult Beagle Dogs

Abstract

Introduction. The efficacy of hydroxocobalamin for acute cyanide poisoning was compared with that of saline vehicle in dogs. Methods. Anesthetized adult beagle dogs were administered potassium cyanide (0.4 mg/kg/min, IV) until 3 min after the onset of apnea. Hydroxocobalamin (75 mg/kg [n = 19] or 150 mg/kg [n = 18], IV) or saline vehicle [n = 17] was then infused over 7.5 min while animals were ventilated with 100% oxygen, which was stopped after 15 min. Results. In vehicle-treated animals cyanide produced deterioration that culminated in a moribund state requiring euthanasia within 4 h in 10 of 17 animals and in neurological deficits necessitating euthanasia within 2–4 d in an additional 4 animals (mortality rate 82%). Survival through 14 d was observed in 15 of 19 animals administered hydroxocobalamin 75 mg/kg (mortality rate 21%), and 18 of 18 administered hydroxocobalamin 150 mg/kg (mortality rate 0%). Conclusion. Hydroxocobalamin reversed cyanide toxicity and reduced mortality in a canine model.

Keywords :

• Hydroxocobalamin
• Cyanides
• Antidotes