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Research Article

Quantitative measurement of cyanide released from Prussian Blue

, Ph.D. , DVM, , B.S., , Ph.D., , Ph.D., , Ph.D., , Ph.D., , Ph.D., , Ph.D., , M.D., , M.D., , Ph.D. & , Ph.D. show all
Pages 776-781 | Received 16 Oct 2006, Accepted 19 Dec 2006, Published online: 20 Jan 2009
 

Abstract

Background. Prussian Blue (PB), ferric hexacyanoferrate is indicated for (oral) treatment of internal contamination with radioisotopes of cesium or thallium. Cyanide is 35–40% of PB's molecular composition, thus cyanide may be released during transit through the digestive tract under physiological pH. The U.S. Food and Drug Administration investigated the issue of cyanide release prior to drug approval to ensure the drug's benefits exceeded risks. Objectives. To determine cyanide released from PB under pH conditions that bracket human physiological exposure. Methods. PB was incubated in situ at pH 1.0–12, 37°C for 1–48 hours. Cyanide was measured using a validated colorimetric method by UV-VIS spectroscopy. Results. PB had the highest cyanide release at pH 1 (135 ug/g) and lowest release at pH 5.0–7.0 from the highest daily dose of PB (17.5 g) (21 ug/g). Considering the minimal lethal dose of cyanide is approximately 50 mg, the maximal cyanide released (1.6 mg) does not present a safety concern.

Acknowledgments

The authors wish to acknowledge the contribution of Dr. Mansoor A. Khan for his helpful comments and insightful review of this article. The authors also wish to thank Dr. Moheb M. Nasr for his valuable scientific and project administration of this study.

Notes

* This scientific contribution is intended to support regulatory policy development. The views presented in this article have not been adopted as regulatory policies by the Food and Drug Administration at this time.

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