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Clinical Toxicology Volume 46, 2008 - Issue 4
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Research Article

Cibenzoline intoxication: Effect of combined hemoperfusion-hemodialysis on plasma clearance

Roel Meeus Departments of Critical Care Medicine, University Hospital of Antwerp,
,
Gert A. Verpooten Department of Nephrology, University Hospital of Antwerp, Edegem, Belgium
,
Rudi De Paep Departments of Critical Care Medicine, University Hospital of Antwerp,
,
Bernard P. Paelinck Department of Cardiology, University Hospital of Antwerp, Edegem, Belgium
,
Hugo Neels Belgium Laboratory of Toxicology, University of Antwerp and ZNA Stuivenberg, Antwerp, Belgium
,
Sarah Cooreman Belgium Laboratory of Toxicology, University of Antwerp and ZNA Stuivenberg, Antwerp, Belgium
,
Mireille De Doncker Belgium Laboratory of Toxicology, University of Antwerp and ZNA Stuivenberg, Antwerp, Belgium
&
Philippe G. Jorens Departments of Critical Care Medicine, University Hospital of Antwerp,
 show all
Pages 303-306 | Received 21 Aug 2006, Accepted 17 May 2007, Published online: 07 Oct 2008
 
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Abstract

Introduction. Cibenzoline is an antiarrhythmic drug used to treat patients with supraventricular or ventricular arrhythmias. Cibenzoline overdose is associated with proarrhythmic and hemodynamic effects such as hypotension and congestive heart failure. Case Report. We report a case of cardiogenic shock due to cibenzoline overdose in a patient with progressive renal insufficiency. Discussion. The standard treatment of a cibenzoline intoxication is symptomatic, but we used combined hemoperfusion-hemodialysis to treat our patient. Conclusions. This was associated with a rapid decline in plasma cibenzoline concentration and improvement of the clinical condition. However, only 28.98 mg of an estimated body pool of cibenzoline (447.2 to 806.6 mg) was removed during the 8 hours of treatment.

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