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Clinical Toxicology Volume 47, 2009 - Issue 7
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Brief Communication

Liver injury associated with the use of Fructus Psoraleae (Bol-gol-zhee or Bu-gu-zhi) and its related proprietary medicine

Wing I Cheung Division of Gastroenterology and Hepatology, Department of Medicine and Geriatrics, United Christian Hospital, Hong Kong SAR, ChinaCorrespondence[email protected]
,
Man Li Tse Hong Kong Poison Information Centre, Hospital Authority, United Christian Hospital, Hong Kong SAR, China
,
Teresa Ngan Chinese Medicine Section, Chief Pharmacist's Office, Hospital Authority, Hong Kong SAR, China
,
Jieru Lin Chinese Medicine Section, Chief Pharmacist's Office, Hospital Authority, Hong Kong SAR, China
,
Ws Ken Lee Chinese Medicine Section, Chief Pharmacist's Office, Hospital Authority, Hong Kong SAR, China
,
Wing Tat Poon Department of Pathology, Toxicology Reference Laboratory, Hospital Authority, Princess Margaret Hospital, Hong Kong SAR, China
,
Tony Wl Mak Department of Pathology, Toxicology Reference Laboratory, Hospital Authority, Princess Margaret Hospital, Hong Kong SAR, China
,
Vincent King Sun Leung Division of Gastroenterology and Hepatology, Department of Medicine and Geriatrics, United Christian Hospital, Hong Kong SAR, China
&
Tai Nin Chau Division of Gastroenterology and Hepatology, Department of Medicine and Geriatrics, United Christian Hospital, Hong Kong SAR, China
 show all
Pages 683-685 | Received 09 Mar 2009, Accepted 21 May 2009, Published online: 30 Jul 2009
 
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Abstract

Fructus Psoraleae (FP) is used by herbalists for the treatment of postmenopausal osteoporosis, vitiligo, and psoriasis. It is used alone, or in combination with other herbs, in some countries in the form of proprietary medicine. It is recognized as one of the emerging hepatotoxins and here we report three cases of acute hepatitis after exposed to FP and its related proprietary medicine. It seems possible that psoralen and its related chemicals may be responsible for the hepatotoxicity. Decoction with other herbs may result in higher concentration of toxic constituents and in more severe liver injury. In summary, FP is associated with hepatotoxicity in some individuals. Pharmacovigilance for the potential side effects of herbal products is necessary.

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