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Cutaneous and Ocular Toxicology Volume 25, 2006 - Issue 2
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Research Article

Expression Profiling of Human Epidermal Keratinocyte Response Following 1-Minute JP-8 Exposure

Chi-Chung Chou Department of Veterinary Medicine and Veterinary Medicine Teaching Hospital, National Chung-Hsing University, Taichung, Taiwan, ROC
,
Jen-Hung Yang Department of Dermatology, Chung-Shan Medical University Hospital, Taichung, Taiwan, ROC
,
San-Duo Chen Institute of Veterinary Pathology, College of Veterinary Medicine, National Chung-Hsing University, Taichung, Taiwan, ROC
,
Nancy A. Monteiro-Riviere Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, North Carolina, USA
,
Han-Ni Li Institutes of Biomedical Sciences and Molecular Biology, National Chung-Hsing University, Taichung, Taiwan, ROC
&
Jeremy J. W. Chen Institutes of Biomedical Sciences and Molecular Biology, National Chung-Hsing University, Taichung, Taiwan, ROC
Pages 141-153 | Published online: 10 Oct 2008
 
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Abstract

The cDNA microarray analysis of 9600 expressed sequence tags was performed to examine the gene expression changes in human epidermal keratinocytes after 1-minute JP-8 exposure; 151 genes were identified as JP-8 responsive and classified into 8 clusters by self organization map. Genes involved in basal transcription and translations were up-regulated, whereas genes related to DNA repair, metabolism, and keratin were mostly down-regulated. Genes encoded for growth factors, apoptosis, signal transduction, and adhesion were also altered. These results indicated that human keratinocyte responds to a single dose of JP-8 insult and revealed several cellular processes previously not associated with jet fuel exposure.

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