Abstract
To study the potential for delayed Type IV dermal sensitivity of a new preservative system containing 1,2-hexanediol and caprylyl glycol, 200-subject repeat insult patch tests were performed with a 15% mixture of 1,2-hexanediol and caprylyl glycol (equal parts of the 2 ingredients) in carbomer gel and a cosmetic formulation at an actual use concentration. No delayed Type IV hypersensitivity reactions were observed.
Acknowledgments
This study was performed at TKL Research, Rochelle Park, New Jersey, USA.
Symdiol 68 was supplied by Symrise AG, Teterboro, New Jersey, USA.
Declaration of interest: Stanley Levy is a paid consultant to Revlon. Anthony Dulichan and Michael Helman are employees of Revlon. This work was supported 100% by the Revlon Research Center.