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Research Article

Kidney inflammation and tissue injury induced by scorpion venom: comparison with a nephrotoxic model

ORCID Icon, ORCID Icon, ORCID Icon &
Pages 240-247 | Received 21 Feb 2018, Accepted 23 Feb 2018, Published online: 09 Mar 2018
 

Abstract

The effect of Androctonus australis hector (Aah) venom in comparison with nephrotoxic model was investigated in vivo. Aah venom induced a rapid inflammatory response characterized by recruitment of neutrophil and eosinophil cells, increased levels of cytokines, and lipid peroxidation. These results were in accordance with the histological findings showing structural damage in the nephrons, similar and faster to that induced by cisplatin model. The modifications in renal function parameters as an elevation of blood urea and creatinine levels with a significant increase in the serum aspartate aminotransferase and lactate dehydrogenase were indicative of tissue damages responsible for the renal failure.

Disclosure statement

The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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