The research advances in the mechanism of manganese-induced neurotoxicity

Abstract

Manganese is an indispensable trace element in the growing process of living creature. However, long-term manganese exposure can cause different levels of damage to multiple organs or systems in the body. It can also cause irreversible damage to the nervous system, causing dysfunction of mental and extrapyramidal system. The exact neurotoxic mechanism of manganese is not yet clear, and this brings difficulties to the early prevention and cure of manganese poisoning. The present research progress of the neurotoxic mechanisms induced by manganese is summarized from the aspects of mitochondrial damage, autophagy, endoplasmic reticulum stress, inflammatory stimulation and neurotransmitter metabolism.

Keywords:

• Manganese
• neurotoxicity
• mechanism

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This study was supported by the International Scientific and Technology Cooperation project of Guizhou Province under Grant (G[2014]7012) (Y.L.), Innovative Talent Team Training Project of Zunyi City under Grant ([2015]42) (Y.L.), Foundation of Guizhou Provincial Scientific and Technology Project under Grant ([2017]1215) (Y.L.) and the National Natural Science Foundation of China under Grant (81760582) (Y.L.).