Abstract
The present study aims to investigate the tumor-suppressive inflammatory tendency of Echis coloratus snake venom against colon cancer. For this purpose, venom induced up/down-regulation effects in response to forty types of colon-cancer related pro and anti-tumorigenic inflammatory cells (11 pro-tumorigenic cytokines, 12 anti-tumorigenic cytokines, 9 pro-tumorigenic chemokines, 1 anti-tumorigenic chemokine and 7 pro-tumorigenic growth factors) were measured, in LoVo, HT-29 and HCT-116 colon cancer cells. As a result, the tumor-suppressive inflammatory effects of venom were screened by its capability to significantly up-regulate four anti-tumorigenic cytokines (IL-1RA, IL-7, IL-9 and IL-15) and to down-regulate one pro-tumorigenic cytokines (IL-1β), three pro-tumorigenic chemokines (MCP-1, MCP-3 and RANTES) and two pro-tumorigenic growth factors (G-CSF and PDGF-AA). Moreover, the venom showed significant colon-tumor promoting potential for fifteen inflammatory cells (IFN-γ, IL-1α, IL-13, TNF-α, EOTAXIN, MIP-1β, GRO, MDC, IL-8, FGF2, GM-CSF, VEGF, PDGF-AB/BB, FRACTALKIN and TGF-α). The tendency of E. coloratus venom to exhibit tumor-suppressive inflammatory effects can be effectively used to reduce the growing phase of colon cancer.
Correction Statement
This article has been republished with minor changes. These changes do not impact the academic content of the article.
Acknowledgments
The authors thank to Dr. Mohammad K.D. AL-Sadoon for their great efforts in the process of snake venom isolation.
Disclosure statement
No potential conflict of interest was reported by the author(s).