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This review summarizes the developments in the area of ROMP‐based polymer carriers as well as side‐chain and main‐chain polymer therapeutics during the period of 1993–2007. The promising emergence of ROMP‐derived amphiphilic block copolymers containing therapeutic agents, their assembly into polymer nanoparticles, together with their modification for the targeting group attachment is outlined. Recent application of ROMP‐based side‐chain polymer therapeutics as multivalent scaffolds and the synthesis of DIVEMA‐type main‐chain polymers from ROMP‐active monomers are also discussed. Finally, an outlook on the opportunities and the future directions in the use of ROMP towards the development of the next generation of polymer therapeutics is provided.
Acknowledgements
We thank all coworkers in the Nguyen group for support and fruitful discussions during the preparation of this review, particularly those whose work was cited herein. Dr. Christopher Graves, Mr. Brian R. Stepp, and Ms. Jill Millstone proofread the initial version of this manuscript. Financial support for this work came from the National Institute of Health through a CCNE grant (NCI 1U54 CA119341‐01). Additional support comes from the Air Force Office of Scientific Research (PECASE Grant F49620‐01‐1‐0303), National Science Foundation (DMR‐CAREER Grant 0094347, EEC‐0647560 through the NSEC program, and DMR‐0520523 through the MRSEC program), the Packard Foundation, and the Sloan Foundation. D. Smith is an ARCS scholar and a Malkin Fellow. E. Pentzer is an NSF graduate research fellow.