Effect of Physicochemical Properties of Biodegradable Polymers on Nano Drug Delivery

Abstract

This review article is to explore the utilization of biodegradable polymers and their associated physicochemical properties in nano drug delivery (NDD). The main hub of the pharma industry is involved in the development of innovative biodegradable and biocompatible polymers which have targeting ability and a predictable release profile of an incorporated active pharmaceutical ingredient (API) or therapeutic agents. Moreover, the pharmaceutical and biological efficiency of the nano drug delivery system varies with the inherent properties of the polymer. The foremost, important physicochemical properties of biodegradable polymers include molecular weight, hydrophobicity, surface charge, crystallinity, composition of the co-polymer, glass transition temperature, and the nature of coating material. Nevertheless, these properties can be manipulated to modify the kinetics of the delivery system by selecting an optimum polymer (based on physicochemical properties) for a specific purpose.

Keywords:

• Biodegradable polymers
• physicochemical properties
• drug release
• nano drug delivery

Acknowledgment

The authors wish to thank the Management of PDM Religious and Educational Association (PDMREA) and are also grateful to the PDM College of Pharmacy, Sarai Aurangabad, Bahadurgarh, Haryana, India for support to carry out this work.